The approach in TACTICS is based on the following principles:
- Use of animal models with excellent face, construct and predictive validity, develop new animals models of compulsivity and match these to human data.
- Study compulsivity as a cross-disorder trait in relation to normal and abnormal functioning of the fronto-striatal circuits.
- Use of Bayesian machine learning as an integrative statistical tool.
- Pilot test new medication in animals and humans to improve functioning of the fronto-striatal circuits