Radboud University Nijmegen Medical Centre
Donders Institute for Brain, Cognition and Behaviour,
Centre for Neuroscience
Human Genetics & Psychiatry
PO Box 9101
6500 HB Nijmegen
The Netherlands
Website

 

Project leader

Prof. Dr. Barbara Franke
 
Phone +31 (0)24 36 14017
Fax +31 (0)24 36 68752
E-Mail  

 

Project staff

Dr. Alejandro Arias Vasquez
 
Phone +31 (0)24 36 14017
Fax +31 (0)24 3668752
E-Mail  

 

Dr. Geert Poelmans
 
Phone +31 (0)24 36 14017
Fax +31 (0)24 36 68752
E-Mail  

 

Janita Bralten
 
Phone +31 (0)24 36 16722
Fax +31 (0)24 36 68752
E-Mail  

 

Marlies Naber
 
Phone +31 (0)24 36 14017
Fax +31 (0)24 36 68752
E-Mail  

Institute presentation

The Department of Human Genetics of our institute, where WP5 will be carried out, is one of the top-ranking genetics groups, internationally. In 2010 alone, 15 papers from this department were published in Nature Genetics. The facilities available to this project include 2 Affymetrix Genechip analyzers (for GWAS and expression profiling), 4 Solid machines (for next generation sequencing), 2 Taqman 7900 HT machines (for genotyping), 5 Genetic Analyzers (for Sanger sequencing) and various liquid handlers. Expertise for the proposed project includes genetic epidemiologists and bioinformaticians in addition to experienced lab technicians.

With regard to the genetics of psychiatric disorders, in close collaboration with the Department of Psychiatry (J. Buitelaar) they have been part of the first genome-wide association studies for ADHD and schizophrenia, they have published linkage analyses of ADHD sib pairs and ADHD-related quantitative traits. In addition, they have performed novel gene-wide analyses of disorder-related genes as well as genome-wide linkage analyses of neuropsychological and brain-structural intermediate phenotypes for psychiatric disorders.

 

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TACTICS has assembled a strong multidisciplinary team of preclinical and clinical top researchers.

To facilitate the organisation and management, the project is structured in “Work Packages” which together comprise the project.